Treadmill walking exercise training and brain function in multiple sclerosis: Preliminary evidence setting the stage for a network-based approach to rehabilitation
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Original versionSandroff, B. M., Wylie, G. R., Sutton, B. P., Johnson, C. L., DeLuca, J., & Motl, R. W. (2018). Treadmill walking exercise training and brain function in multiple sclerosis: Preliminary evidence setting the stage for a network-based approach to rehabilitation. Multiple Sclerosis Journal - Experimental, Translational and Clinical. http://dx.doi.org/10.1177/2055217318760641
Exercise training has been identified as a highly promising approach for managing the cognitive consequences of multiple sclerosis (MS). This study represents a secondary analysis of resting-state functional connectivity (RSFC) magnetic resonance imaging data from a pilot treadmill walking exercise training intervention for improving cognitive processing speed (CPS) in MS. There were large intervention effects on RSFC between the thalamus and right superior frontal gyrus (d = 1.92) and left medial frontal gyrus (d = 1.70). There further were moderate-to-large intervention effects on CPS (d = 0.72). Such preliminary data highlight FC within thalamocortical circuitry as a potential target for rehabilitation interventions for improving CPS in cognitively impaired individuals with MS.