Methylome dynamics during different stages of CMV infection
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Human cytomegalovirus (HCMV) is part of the Herpesvirus family, and can replicate in a wide range of cells. As HCMV sheds through urine and saliva, it establishes a high level of seropositive individuals in the society. Several cell lineages are believed to be main reservoirs for harbouring HCMV during latency, which is preserved throughout the hosts lifespan. HCMV has abilities that enables escape from the immune system and cellular responses. It is known that epigenetic modifications of HCMV play an important role in gene regulation during infection. These epigenetic mechanisms are crucial to keep the virus in latent state, as well as reactivation of the virus. To understand how these epigenetic mechanisms work, to see how mRNA are epigenetically modified, and understanding the role of N1-methyladenosine (m1A) and N6-methyladenosine (m6A) in mRNA, can give potential strategies for therapies in the future.
Master's thesis in Biological chemistry