Reduced appendicular lean body mass, muscle strength, and size of type II muscle fibers in patients with spondyloarthritis versus healthy controls: a cross-sectional study
Journal article, Peer reviewed
MetadataVis full innførsel
- Artikler / Articles 
OriginalversjonThe Scientific World Journal. 2016, 2016, 1-12. doi: http://dx.doi.org/10.1155/2016/6507692 http://dx.doi.org/10.1155/2016/6507692
Introduction:The purpose of this study was to investigate body composition, muscle function, and muscle morphology in patients with spondyloarthritis (SpA). Methods: Ten male SpA patients (mean ± SD age 39 ± 4.1 years) were compared with ten healthy controls matched for sex, age, body mass index, and self-reported level of physical exercise. Body composition was measured by dual energy X-ray absorptiometry. Musculus quadriceps femoris (QF) strength was assessed by maximal isometric contractions prior to test of muscular endurance. Magnetic resonance imaging of QF was used to measure muscle size and calculate specific muscle strength. Percutaneous needle biopsy samples were taken from m. vastus lateralis. Results: SpA patients presented with significantly lower appendicular lean body mass (LBM) (𝑝� = 0.02), but there was no difference in bone mineral density, fat mass, or total LBM. Absolute QF strength was significantly lower in SpA patients (𝑝� = 0.03) with a parallel trend for specific strength (𝑝� = 0.08). Biopsy samples from the SpA patients revealed significantly smaller cross-sectional area (CSA) of type II muscle fibers (𝑝� = 0.04), but no difference in CSA type I fibers. Conclusions: Results indicate that the presence of SpA disease is associated with reduced appendicular LBM, muscle strength, and type II fiber CSA.