Migraine and endothelial function
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Background: Reduced endothelial function is associated with elevated risk of cardiovascular disease, but evidence on the association between migraine and endothelial function is conflicting. The aim of this population-based study was to examine the relationship between flow-mediated dilatation (FMD) and migraine with aura, migraine without aura and tensiontype headache. Methods: In the third Nord-Trøndelag Health Study (HUNT3) FMD was measured by ultrasound during reactive hyperemia of the brachial artery in a sample of 4,739 healthy adult participants, whereof 3,929 answered headache questions. The cross-sectional association between different headache diagnoses and FMD was evaluated by logistic regression, using a categorical approach. Results: Mean FMD did not differ between the headache groups and headache-free controls. In multiadjusted analyses, no consistent association was found between FMD quintiles and headache groups. No association was found between endothelial dysfunction (defined as FMD ≤ 0 %) and the different headache groups. Conclusions: There was no relationship between FMD and migraine or other headache diagnoses in this large cross-sectional study of otherwise healthy respondents.