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dc.contributor.authorTollefsen, Knut Erik
dc.contributor.authorBæk, Kine
dc.contributor.authorAlmeida, Ana
dc.contributor.authorHaug, Linn Anette
dc.contributor.authorNorli, Hans
dc.contributor.authorOdenmarck, Sven
dc.contributor.authorStenrød, Marianne
dc.contributor.otherTollefsen, Knut Erik - Project manager
dc.identifier.citationNIVA-rapport. 30 p. Norsk institutt for vannforskning, 2016nb_NO
dc.description.abstractThis project evaluated whether the principles of combined toxicity assessment (CTA) and cumulative risk assessment (CRA) can be used to predict the toxicity of ecologically-relevant mixtures of plant protection products (PPPs) in surface waters receiving run-off from Norwegian agricultural areas. A combination of testing solid phase extracts (SPE), whole surface water and a synthetic mixture in an algal bioassay and predicting combined toxicity using CTA models were conducted on selected samples from the Heia catchment (Råde, Norway). The results demonstrated that designing and testing synthetic mixtures on the basis of measured concentrations of PPPs was the best method for the accurate determination of combined toxicity due to confounding factors introduced by whole water and SPE testing. Combined toxicity models based on Concentration Addition (CA) successfully predicted the toxicity of the complex synthetic mixture and verified that a mixture of PPPs acted in an additive manner. Tiered assessment of the cumulative risk of active PPP substances and PPP formulations proposed by the European Food Safety Authority (EFSA) were considered applicable also for the CRA of complex environmental mixtures and could potentially aid the identification of relevant mixtures, risk drivers and susceptible species as input to the assessment and approval of PPPs.nb_NO
dc.description.sponsorshipMattilsynet; Norwegian Food Safety Authoritynb_NO
dc.publisherNorsk institutt for vannforskningnb_NO
dc.rightsNavngivelse-Ikkekommersiell-DelPåSammeVilkår 3.0 Norge*
dc.titleEvaluation of the combined toxicity assessment and cumulative risk assessment of ecologically relevant mixtures of plant protection Products (PPPs) under Norwegian conditionsnb_NO
dc.typeResearch reportnb_NO
dc.rights.holderNorsk institutt for vannforskning / Norwegian institute for water researchnb_NO
dc.subject.nsiVDP::Matematikk og naturvitenskap: 400nb_NO
dc.subject.nsiVDP::Mathematics and natural scienses: 400nb_NO
dc.subject.keywordKombinerte effekter / Combined effects
dc.subject.keywordKumulativ risikovurdering / Cumulative risk assessment
dc.subject.keywordPlantevernmidler / Plant protection products
dc.subject.keywordRegulatorisk godkjenning / Regulatory approval

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Navngivelse-Ikkekommersiell-DelPåSammeVilkår 3.0 Norge
Except where otherwise noted, this item's license is described as Navngivelse-Ikkekommersiell-DelPåSammeVilkår 3.0 Norge