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Epidemiology and classification of gastroenteropancreatic neuroendocrine neoplasms using current coding criteria
Journal article, Peer reviewed
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Original versionSandvik, O.M. et al. (2015) Epidemiology and classification of gastroenteropancreatic neuroendocrine neoplasms using current coding criteria Epidemiology and classification of gastroenteropancreatic neuroendocrine neoplasms using current coding criteria. British Journal of Surgery 2015, 103(3), pp. 226-232 10.1002/bjs.10034
Background: The lack of uniform criteria for coding of gastroenteropancreatic neuroendocrine neoplasia (GEP-NEN) has hampered previous epidemiological studies. The epidemiology of GEP-NEN was investigated in this study using currently available criteria. Methods: All patients diagnosed with GEP-NEN between January 2003 and December 2013 in a well defined Norwegian population of approximately 350000 people were included. Age- and sex-adjusted incidence rates were calculated. The current 2010 World Health Organization criteria, European Neuro- endocrine Tumour Society classification and International Union Against Cancer (UICC) classification were used. Results: A total of 204 patients (114 male, 55 ⋅ 9 per cent) were identified. The median age at diagnosis was 61 (range 10–94) years. The annual overall crude incidence was 5⋅83 per 100000 inhabitants, with an increasing trend (P=0⋅033). The most frequent location was small intestine (60 patients, 29⋅4 per cent) followed by appendix (48 patients, 23⋅5 per cent) and pancreas (33 patients, 16⋅2 per cent). Grade 1 tumours were more common in gastrointestinal (100 patients, 58⋅5 per cent) than in pancreatic (9 patients, 27 per cent) NEN. According to the UICC classification, 77 patients (37⋅7 per cent) had stage I, 17 patients (8⋅3 per cent) stage II, 37 patients (18⋅1 per cent) stage III and 70 patients (34⋅3 per cent) had stage IV disease. No patient with stage I disease had grade 3 tumours; advanced tumour grade increased with stage. Conclusion: A high crude incidence of GEP-NEN, at 5⋅83 per 100000 inhabitants, was noted together with a significant increasing trend over time,
BJS published by John Wiley & Sons Ltd on behalf of BJS Society Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.