Synthesis of Novel Homo-N-Nucleoside Analogs Composed of a Homo-1,4-Dioxane Sugar Analog and Substituted 1,3,5-Triazine Base Equivalents
Journal article, Peer reviewed
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Original versionMolecules 2008, 13(12):3092-3106 10.3390/molecules13123092
Enantioselective syntheses from dimethyl tartrate of 1,3,5-triazine homo-Nnucleoside analogs, containing a 1,4-dioxane moiety replacing the sugar unit in natural nucleosides, were accomplished. The triazine heterocycle in the nucleoside analogs was further substituted with combinations of NH2, OH and Cl in the 2,4-triazine positions.