Recent Submissions

  • Representation of geometric borders in the developing rat 

    Bjerknes, Tale Litlere; Moser, Edvard Ingjald; Moser, May-Britt (Journal article; Peer reviewed, 2014)
    Local space is represented by a number of functionally specific cell types, including place cells in the hippocampus and grid cells, head direction cells, and border cells in the medial entorhinal cortex (MEC). These cells ...
  • Interaction of nucleus reuniens and entorhinal cortex projections in hippocampal field CA1 of the rat 

    Dolleman-van der Weel, M. J.; Lopes da Silva, F.H.; Witter, Menno (Journal article; Peer reviewed, 2016)
    The nucleus reuniens (RE) and entorhinal cortex (EC) provide monosynaptic excitatory inputs to the apical dendrites of pyramidal cells and to interneurons with dendrites in stratum lacunosum moleculare (LM) of hippocampal ...
  • Architecture of spatial circuits in the hippocampal region 

    Witter, Menno; Canto, Cathrin Barbara; Couey, Jonathan Jay; Koganezawa, Noriko; O'Reilly, Kally (Journal article; Peer reviewed, 2014)
    The hippocampal region contains several principal neuron types, some of which show distinct spatial firing patterns. The region is also known for its diversity in neural circuits and many have attempted to causally relate ...
  • Parahippocampal and retrosplenial connections of rat posterior parietal cortex 

    Olsen, Grethe Mari; Ohara, Shinya; Iijima, Toshio; Witter, Menno (Journal article; Peer reviewed, 2017)
    The posterior parietal cortex has been implicated in spatial functions, including navigation. The hippocampal and parahippocampal region and the retrosplenial cortex are crucially involved in navigational processes and ...
  • Integration of grid maps in merged environments 

    Wernle, Tanja; Waaga, Torgeir; Mørreaunet, Maria; Treves, Alessandro; Moser, May-Britt; Moser, Edvard Ingjald (Journal article; Peer reviewed, 2018)
    Natural environments are represented by local maps of grid cells and place cells that are stitched together. The manner by which transitions between map fragments are generated is unknown. We recorded grid cells while rats ...
  • Hippocampal Remapping after Partial Inactivation of the Medial Entorhinal Cortex 

    Miao, Chenglin; Cao, Qichen; Ito, Hiroshi; Yamahachi, Homare; Witter, Menno; Moser, May-Britt; Moser, Edvard Ingjald (Journal article; Peer reviewed, 2015)
    Hippocampal place cells undergo remapping when the environment is changed. The mechanism of hippocampal remapping remains elusive but spatially modulated cells in the medial entorhinal cortex (MEC) have been identified as ...
  • Postnatal development of retrosplenial projections to the parahippocampal region of the rat 

    Sugar, Jørgen; Witter, Menno (Journal article; Peer reviewed, 2016)
    The rat parahippocampal region (PHR) and retrosplenial cortex (RSC) are cortical areas important for spatial cognition. In PHR, head-direction cells are present before eye-opening, earliest detected in postnatal day (P)11 ...
  • Correlations and functional connections in a population of grid cells 

    Dunn, Benjamin Adric; Mørreaunet, Maria; Roudi, Yasser (Journal article; Peer reviewed, 2015)
    We study the statistics of spike trains of simultaneously recorded grid cells in freely behaving rats. We evaluate pairwise correlations between these cells and, using a maximum entropy kinetic pairwise model (kinetic Ising ...
  • Monitoring multiple myeloma by quantification of recurrent mutations in serum 

    Rustad, Even Holth; Coward, Eivind; Skytøen, Emilie R; Misund, Kristine; Holien, Toril; Standal, Therese; Børset, Magne; Beisvag, Vidar; Myklebost, Ola; Meza, Leonardo Zepeda; Hong, Yan Dai; Sundan, Anders; Waage, Anders (Journal article; Peer reviewed, 2017)
    Circulating tumor DNA is a promising biomarker to monitor tumor load and genome alterations. We explored the presence of circulating tumor DNA in multiple myeloma patients and its relation to disease activity during long-term ...
  • Posterior parietal cortex of the rat: Architectural delineation and thalamic differentiation 

    Olsen, Grethe Mari; Witter, Menno (Journal article; Peer reviewed, 2016)
    This study refines the characterization of the rat parietal cortical domain in terms of cyto- and chemoarchitecture as well as thalamic connectivity. We recognize three subdivisions of the posterior parietal cortex (PPC), ...
  • Coordination of entorhinal-hippocampal ensemble activity during associative learning 

    Igarashi, Kei M; Lu, Li; Colgin, Laura Lee; Moser, May-Britt; Moser, Edvard Ingjald (Journal article; Peer reviewed, 2014)
    Accumulating evidence points to cortical oscillations as a mechanism for mediating interactions among functionally specialized neurons in distributed brain circuits1, 2, 3, 4, 5, 6. A brain function that may use such ...
  • Functional diversity along the transverse axis of hippocampal area CA1 

    Igarashi, Kei M; Ito, Hiroshi; Moser, Edvard Ingjald; Moser, May-Britt (Journal article; Peer reviewed, 2014)
    Decades of neuroscience research have shed lights on the hippocampus as a key structure for the formation of episodic memory. The hippocampus is divided into distinct subfields – CA1, CA2 and CA3. Whereas accumulating ...
  • Stellate cells drive maturation of the entorhinal-hippocampal circuit 

    Donato, Flavio; Jacobsen, R Irene; Moser, May-Britt; Moser, Edvard I (Journal article; Peer reviewed, 2017)
    The neural representation of space relies on a network of entorhinal-hippocampal cell types with firing patterns tuned to different abstract features of the environment. To determine how this network is set up during early ...
  • Perirhinal firing patterns are sustained across large spatial segments of the task environment 

    Bos, Jeroen J.; Vinck, Martin; van Mourik-Donga, Laura; Jackson, Jadin C.; Witter, Menno; Pennartz, Cyriel M.A. (Journal article; Peer reviewed, 2017)
    Spatial navigation and memory depend on the neural coding of an organism’s location. Fine-grained coding of location is thought to depend on the hippocampus. Likewise, animals benefit from knowledge parsing their environment ...
  • Physiological properties of neurons in bat entorhinal cortex exhibit an inverse gradient along the dorsal–ventral axis compared to entorhinal neurons in rat 

    Heys, James G; Shay, Christopher F; MacLeod, Katrina M; Witter, Menno; Moss, Cynthia F; Hasselmo, Michael E (Journal article; Peer reviewed, 2016)
    Medial entorhinal cortex (MEC) grid cells exhibit firing fields spread across the environment on the vertices of a regular tessellating triangular grid. In rodents, the size of the firing fields and the spacing between the ...
  • MicroRNAs contribute to postnatal development of laminar differences and neuronal subtypes in the rat medial entorhinal cortex 

    Olsen, Lene Christin; O'Reilly, Kally; Liabakk, Nina-Beate; Witter, Menno; Sætrom, Pål (Journal article; Peer reviewed, 2017)
    The medial entorhinal cortex (MEC) is important in spatial navigation and memory formation and its layers have distinct neuronal subtypes, connectivity, spatial properties, and disease susceptibility. As little is known ...
  • Architecture of the entorhinal cortex A review of entorhinal anatomy in rodents with some comparative notes 

    Witter, Menno; Doan, Thanh Pierre; Nilssen, Eirik Stamland; Jacobsen, Bente; Ohara, Shinya (Journal article; Peer reviewed, 2017)
    The entorhinal cortex (EC) is the major input and output structure of the hippocampal formation, forming the nodal point in cortico-hippocampal circuits. Different division schemes including two or many more subdivisions ...
  • Comparative Contemplations on the Hippocampus 

    Witter, Menno; Kleven, Heidi; Kobro-Flatmoen, Asgeir (Journal article; Peer reviewed, 2017)
    The hippocampus in mammals is a morphologically well-defined structure, and so are its main subdivisions. To define the homologous structure in other vertebrate clades, using these morphological criteria has been difficult, ...
  • Grid cells and cortical representation 

    Moser, Edvard Ingjald; Roudi, Yasser; Witter, Menno; Kentros, Clifford; Bonhoeffer, Tobias; Moser, May-Britt (Journal article; Peer reviewed, 2014)
    One of the grand challenges in neuroscience is to comprehend neural computation in the association cortices, the parts of the cortex that have shown the largest expansion and differentiation during mammalian evolution and ...
  • Waxholm Space atlas of the rat brain hippocampal region: Three-dimensional delineations based on magnetic resonance and diffusion tensor imaging 

    Kjønigsen, Lisa Jannicke; Lillehaug, Sveinung; Bjaalie, Jan G.; Witter, Menno; Leergaard, Trygve Brauns (Journal article; Peer reviewed, 2015)
    Atlases of the rat brain are widely used as reference for orientation, planning of experiments, and as tools for assigning location to experimental data. Improved quality and use of magnetic resonance imaging (MRI) and ...

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